Peyronie's Disease

Peyronie's disease (PD) is a condition, seen in ~3-10% of men, in which scar tissue develops within the fibrous tissue (tunica albuginea) surrounding the erectile chambers of the penis, resulting in penile curvature, indentation, shortening, pain, or difficulty with sexual intercourse.

PD is most commonly diagnosed in middle-aged and older men, although it can occur at any age.

Evaluation includes a detailed sexual history and examination of the penis, with assessment of the degree and nature of the deformity and erectile function. When appropriate, an in-office medication injection and penile duplex ultrasound can help characterize the deformity and erectile function.

Treatment depends on whether the disease is active or stable (meaning progressing or stable for a period of time without significant change), the severity of the deformity, symptoms, and erectile function.

Treatment options range from observation and medical management to penile traction therapy, intralesional therapy such as collagenase (Xiaflex), and reconstructive penile straightening surgery. Men with severe deformity and associated erectile dysfunction may ultimately benefit from penile prosthesis surgery.