Radical prostatectomy, radical cystectomy, and other pelvic surgeries can affect the nerves and blood vessels responsible for erections and are common causes of post-surgical erectile dysfunction.

Penile rehabilitation focuses on maintaining erectile tissue health and maximizing the potential for recovery of erectile function and penile length.

Treatment may include PDE5 inhibitors, vacuum erection devices, intracavernosal injections, and other therapies, with penile prosthesis surgery an option for men with persistent, treatment-resistant ED.